… profiles in a clinical trial of a candidate antidepressant. The model is able to describe an …
of identifying antidepressant drug candidates based on nonclinical models of depression. A …

… actions of antidepressants are well characterised but our understanding of how these …
consistent with the effects of antidepressants in healthy volunteer models, although so far most of …

… models have been essential to our understanding of the phar! macology of antidepressants\
… the clinical relevance of these models[ Indeed\ animal models are simple experimental …

… depression and remediated by antidepressant treatments. In this paper, we evaluate the
ability of RL models to help us understand the processes underlying antidepressant action. To …

… approaches to understanding of the delayed clinical effects of antidepressant drug action, …
to increase synaptic plasticity has been directly tested in well designed rodent models, …

… antidepressant adherence have yielded disappointing findings, 15 – 19 a better understanding
of treatment beliefs may help … We fitted separate regression models to determine which …

… recently turned attention to understanding how nonremission to antidepressant treatments
itself may represent a marker of illness severity and, in turn, help predict illness course and …

… Over the last three decades, our understanding of the … than animal models, our model of
antidepressant drug action has … Importantly, as will be discussed later, our models of emotional …

… radically our understanding of the biology of stress and the effects of antidepressant agents.
… antagonists themselves have antidepressant properties in animal models that predict the …

… A better understanding of drug-related seizure risk, its predictors, … trials of antidepressants
to determine antidepressant-related … Electrophysiologic and in vitro models of drug-related …